2023
Begg, KAG, H Braun, N Ghaddar, L Wu, and JA Downs (2023) Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses. DNA Repair, in press.
Pantelejevs, T, P Zuazua-Villar, O Koczy, AJ Counsell, SJ Walsh, NS Robertson, DR Spring, JA Downs, and M Hyvonen (2023) A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chemical Science, advance online article.
2022
Feng, H, KA Lane, TI Roumeliotis, PA Jeggo, N Somaiah, JS Choudhary, and JA Downs (2022) PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance. Genes Dev. Doi: 10.1101/gad.349249.121.
Schiavoni, F, P Zuazua-Villar, TI Roumeliotis, G Benstead-Hume, M Pardo, FMG Pearl, JS Choudhary, and JA Downs (2022) Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness. Nat Commun. 13(1):1731.
2021
Lindenburg, LH, T Pantelejevs, F Gielen, P Zuazua-Villar, M Butz, E Rees, CF Kaminski, JA Downs, M Hyvonen, and F Hollfelder (2021) Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats. Proc Natl Acad Sci118(46):e2017708118.
Chabanon, RM, D Morel, T Eychenne, L Colmet-Daage, I Bajrami, N Dorvault, M Garrido, C Meisenberg, A Lamb, C Ngo, SR Hopkins, TI Roumeliotis, S Jouny, C Henon, A Kawai-Kawachi, C Astier, A Konde, E Del Nery, C Massard, SJ Pettitt, R Margueron, JS Choudhary, G Almouzni, JC Soria, E Deutsch, JA Downs, CJ Lord and S Postel-Vinay (2021) PBRM1 deficiency confers synthetic lethality to DNA repair inhibitors in cancer. Cancer Research 81(11):2888-2902.
Wilkins, A, E Fontana, G Nyamundanda, C Ragulan, Y Patil, D Mansfield, J Kingston, F Errington-Mais, D Bottomley, K von Loga, H Bye, P Carter, E Tinkler-Hundal, A Noshirwani, JA Downs, M Dillon, S Demaria, D Sebag-Montefiore, K Harrington, N West, A Melcher and A Sadanandam (2021) Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer. J Immunother Cancer 9(3):e001717.
Flaus, A, JA Downs, and T Owen-Hughes (2021) Histone isoforms and the oncohistone code. Curr Opin Genet Dev 67:61-66.
Anbalagan, S, C Strom, JA Downs, PA Jeggo, D McBay, A Wilkins, K Rothkamm, KJ Harrington, JR Yarnold, N Somaiah (2021) TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells. Sci Reports 11(1):7119.
2020
Rother, MB, S Pellegrino, R Smith, M Gatti, C Meisenberg, WW Wiegant, MS Luijsterburg, R Imhof, JA Downs, ACO Vertegaal, S Huet, M Altmeyer, and H van Attikum (2020) CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks. Nat Commun 11(1):5775.
Harrod, A, KA Lane, and JA Downs (2020) The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks. DNA Repair 93:102919.
2019
Benstead-Hume, G, SK Wooller, JA Downs, and FMG Pearl (2019) Defining signatures of arm-wise copy number change and their associated drivers in kidney cancers. Int J Mol Sci, 20(22):E5762.
Benstead-Hume, G, X Chen, SR Hopkins, KA Lane, JA Downs, and FMG Pearl (2019) Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. PLoS Comput Biol, 15(4):e1006888.
Meisenberg, C, SI Pinder, SR Hopkins, SK Wooller, G Benstead-Hume, FMG Pearl, PA Jeggo, and JA Downs (2019) Repression of transcription at DNA breaks requires cohesin throughout interphase and prevents genome instability. Molecular Cell, 73(2):212-223.
selected pre-2018 publications
Jeggo, PA, JA Downs, and SM Gasser (2017) Chromatin modifiers and remodellers in DNA repair and signalling. Philos Trans R Soc Lond Biol Sci, 372(1731).
Myrianthopoulos, V, N Gaboriaud-Kolar, C Tallant, ML Hall, S Girgoriou, PM Brownlee, O Fedorov, C Rogers, D Heidenreich, M Wanior, N Drosos, N Mexia, P Savitsky, T Bragratuni, E Kastritis, E Terpos, P Filippakopoulos, S Muller, AL Skaltsounis, JA Downs, S Knapp, and E Mikros (2016) Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. J Med Chem, 50(19):8787-8803.
Hopkins, SR, GA McGregor, JM Murray, JA Downs and V Savic (2016) Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180. DNA Repair, 46:47-54.
Alatwi, H and JA Downs (2015) Removal of H2A.Z by INO80 promotes homologous recombination. EMBO Reports, 16(8):986-94.
Niimi, A, SR Hopkins, JA Downs, and C Masutani (2015) The BAH domain of BAF180 is required for PCNA ubiqutination. Mutat Res, 779: 16-23.
Brownlee, PM, C Meisenberg, and JA Downs (2015) The SWI/SNF chromatin remodelling complex: its role in maintaining genome stability and preventing tumourigenesis. DNA Repair, 6(6): 973-981.
Jeggo, PA and JA Downs (2014) Roles of chromatin remodellers in DNA double strand break repair. Exp Cell Res, 329(1):69-77.
Kakarougkas, A, A Ismail, AL Chambers, E Riballo, AD Herbert, J Kunzel, M Lobrich, PA Jeggo, and JA Downs (2014) Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Molecular Cell, 55(5): 723-732.
Lopez-Perrote A, HE Alatwi, E Torreira, A Ismail, S Ayora, JA Downs* and O Llorca* (2014) Structure of Yin Yang 1 oligomers that cooperate with RuvBL1-RuvBL2 ATPases. J Biol Chem, 289(33): 22614-22629.
*Joint corresponding authors
Brownlee, PM, AL Chambers, R Cloney, A Bianchi, and JA Downs (2014) BAF180 promotes cohesion and prevents genome stability and aneuploidy. Cell Reports, 6(6): 973-981.
Chambers, AL, LH Pearl, AW Oliver, and JA Downs (2013) The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic Acids Research 41(19): 9168-9182.
Chambers, AL, G Ormerod, SC Durley, TL Sing, GW Brown, NA Kent, and JA Downs (2012) The INO80 chromatin remodelling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Genes and Development, 26(23):2590-2603.
Niimi, A, AL Chambers, JA Downs* and AR Lehmann* (2012) A role for chromatin remodellers in replication of damaged DNA. Nucleic Acids Research 40(15): 7393-7403.
*Joint corresponding authors
Brownlee, PM, AL Chambers, AW Oliver, and JA Downs (2012) Cancer and the bromodomains of BAF180. Biochem Soc Trans40(2): 364-369.
Chambers, AL, PM Brownlee, SC Durley, T Beacham, NA Kent, and JA Downs (2012) The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses. PLoS One 7(2):e32016.
Foster, ER and JA Downs (2009) Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. Journal of Cell Biology 184(5): 631-638.
Downs, JA (2008) Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint. DNA Repair 7(12): 2020-2024.
Downs, JA (2007) Chromatin structure and DNA double-strand break responses in cancer progression and therapy. Oncogene 26(56): 7765-7772.
Chambers, AL and JA Downs (2007) The contribution of the budding yeast histone H2A C-terminal tail to DNA-damage responses. Biochem Soc Trans 35(6): 1519-1524.
Kent, NA, AL Chambers and JA Downs (2007) Dual chromatin remodeling roles for RSC during DNA double strand break induction and repair at the yeast MAT locus. Journal of Biological Chemistry 282(38): 27693-27701.
Downs, JA, MC Nussenzweig and A Nussenzweig (2007) Chromatin dynamics and the preservation of genetic information. Nature447(7147):951-958.
Downs, JA and J Cote (2005) Dynamics of chromatin during the repair of DNA double-strand breaks. Cell Cycle 4(10): 1373-1376.
Harvey, AC, SP Jackson and JA Downs (2005) Saccharomyces cerevisiae histone H2A Ser122 facilitates DNA repair. Genetics170(2): 543-553.
Zaid, O and JA Downs (2005) Histones as tumour suppressor genes. Cellular and Molecular Life Sciences 62(15): 1653-1656.
Foster, ER and JA Downs (2005) Histone H2A phosphorylation in DNA double-strand break repair. FEBS Journal 272(13): 3231-3240.
Downs, JA, S Allard, O Jobin-Robitaille, A Javaheri, A Auger, N Bouchard, SJ Kron, SP Jackson, and J Cote (2004) Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Molecular Cell 16(6): 979-990.
Harvey, AC and JA Downs (2004) What functions do linker histones provide? Molecular Microbiology 53(3): 771-775.
Downs, JA and SP Jackson (2004) A means to a DNA end: the many roles of Ku. Nature Reviews Molecular Cell Biology 5(5): 367-378.
Downs, JA and SP Jackson (2003) Cancer – Protective packaging for DNA. Nature 424(6950): 732-734.
Downs, JA, E Kosmidou, A Morgan, and SP Jackson (2003) Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Molecular Cell 11(6): 1685-1692.
Downs, JA, NF Lowndes, and SP Jackson (2000) A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature408(6815): 1001-1004